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KMID : 0604520200460020133
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Journal of the Society of Cosmetic Scientists of Korea
2020 Volume.46 No. 2 p.133 ~ p.145
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Study on the Stability of Biotin-containing Nano-liposome
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Yang Seong-Jun
Kim Tae-Yang
Lee Chun-Mong
Lee Kwang-Sik
Yoon Kyung-Sup
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Abstract
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This study utilized nano-liposomes for the purpose of stabilizing and increasing the solubility of biotin, a water-soluble active material with low solubility. The particle size, zeta potential, and polydispersity index were confirmed with a nano zetasizer. It was possible to manufacture nano liposomes at 100 to 250 nm of particle size and -80 to -30 mV of zeta potential. Dialysis membrane method (DMM) was used to measure the capsulation efficiency of biotin in biotin nano-liposomes, and results showed that pH increased biotin nano-liposomes had higher capsulation efficiency than normal biotin nano-liposome. Through this experiment, it was confirmed that the pH has a great influence on the stability of biotin nano-liposomes. In vitro franz diffusion cell method was used to measure in vitro skin absorption rate of biotin nano-liposomes. The shape of the formulation and biotin solubility in nano-liposome was observed by cryogenic transmission electron microscopy (cryo-TEM). Through this study, we confirmed that biotin, which is introduced as closely related to hair health, can be incorporated into a nano-liposome drug delivery system, to make biotin nano-liposome with improved solubility and precipitation problems.
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KEYWORD
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biotin, stabilization, nano-liposome, cryo-SEM, zetasizer
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